F5557

Fasentin

≥98% (HPLC)

• Synonym(s): N-[4-Chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide
• Empirical Formula (Hill Notation): C₁₁H₉ClF₃NO₂
• CAS Number: 392721-37-8
• Molecular Weight: 279.64
• MDL number: MFCD01001285
• UNSPSC Code: 12352200
• PubChem Substance ID: 329799713
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: DMSO: >10 mg/mL
• storage temp.: room temp
• SMILES string: CC(=O)CC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F
• InChI: 1S/C11H9ClF3NO2/c1-6(17)4-10(18)16-7-2-3-9(12)8(5-7)11(13,14)15/h2-3,5H,4H2,1H3,(H,16,18)
• InChI key: GNYIJZMBLZXJEJ-UHFFFAOYSA-N

Description

Application

Fasentin has been used as a glucose transporter (GLUT1) inhibitor to assess its effects on the vulnerability of a wide range of triple-negative breast cancer (TNBC) cell lines and to study its effects on cytotoxic drugs induced by hydrocortisone (HC).

Biochem/physiol Actions

Fasentin is a novel inhibitor of glucose uptake, GluT1 inhibitor. Fasentin is a novel inhibitor of glucose uptake that sensitizes cells to FAS-induced cell death. Fasentin selectively sensitized to death ligands, but did not decrease FLIP expression. It alters expression of genes associated with nutrient and glucose deprivation. Fasentin interacted with a unique site in the intracellular channel of the glucose transport protein GLUT1.

Fastentin is a novel inhibitor of glucose uptake, GluT1 inhibitor.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable