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F9057

Sigma-Aldrich

FLLL31

≥98% (HPLC)

Synonym(s):

(E,E)-1,7-Bis(3,4-dimethoxyphenyl)-4,4-dimethyl-1,6-heptadiene-3,5-dione, Tetramethylcurcumin

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200 μG
$576.00

About This Item

Empirical Formula (Hill Notation):
C25H28O6
CAS Number:
52328-97-9
Molecular Weight:
424.49
MDL number:
MFCD19443859
UNSPSC Code:
12352200
PubChem Substance ID:
329799781
NACRES:
NA.77

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Assay

≥98% (HPLC)

form

powder

color

yellow

solubility

DMSO: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

COc1ccc(\C=C\C(=O)C(C)(C)C(=O)\C=C\c2ccc(OC)c(OC)c2)cc1OC

InChI

1S/C25H28O6/c1-25(2,23(26)13-9-17-7-11-19(28-3)21(15-17)30-5)24(27)14-10-18-8-12-20(29-4)22(16-18)31-6/h7-16H,1-6H3/b13-9+,14-10+

InChI key

VMMZAMVBGQWOHT-UTLPMFLDSA-N

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Gene Information

human ... ABCG2(9429)

Gene Information

-

Gene Information

human ... ABCA1(19)

Gene Information

bovine ... Gab1(540085)
human ... GAB1(2549)

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified antibody

antibody form

purified antibody

biological source

rabbit (recombinant)

biological source

rabbit

biological source

rabbit

biological source

rabbit (recombinant)

clone

10k5, recombinant monoclonal

clone

recombinant monoclonal

clone

1J11, recombinant monoclonal

clone

4B20, monoclonal, recombinant monoclonal

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

species reactivity

mouse, human

species reactivity

mouse, human

species reactivity

mouse, human

species reactivity

bovine, human

Biochem/physiol Actions

FLLL31 selectively binds to Janus kinase 2 and the STAT3 Src homology-2 (SH2) domain, effective inhibitors of STAT3 phosphorylation.
FLLL31 selectively binds to Janus kinase 2 and the STAT3 Src homology-2 (SH2) domain, effective inhibitors of STAT3 phosphorylation. STAT3 plays a critical role in early embryogenesis, but is largely dispensable in normal adult cells and tissues. On the other hand the JAK2/STAT3 signaling pathway is persistently activated in great number of human solid and blood cancers. Such activation is commonly associated with a worse prognosis. FLLL31 is a curcumin derivative locked in diketone-tautomeric form, which supposedly improves binding to SH2 domain. The compound inhibits JAK2 kinase activity and prevents STAT3 phosphorylation. FLLK31 is a potent and selective inhibitor of the STAT3 signaling pathway.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Hazard Statements

H413

Hazard Classifications

Aquatic Chronic 4

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    BGBC5557V
    052M4608V
    090M4610

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