H157

HOE 140

≥94% (HPLC), powder or lyophilized powder, B₂ bradykinin receptor antagonist

• Synonym(s): D-Arg-L-Arg-L-Pro-L-Hyp-Gly-L-(2-thienyl)Ala-L-Ser-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2α,3β,7aβ)-octahydro-1H-indole-2-carbonyl-L-Arg, Icatibant acetate
• Empirical Formula (Hill Notation): C₅₉H₈₉N₁₉O₁₃S
• CAS Number: 138614-30-9
• Molecular Weight: 1304.52
• MDL number: MFCD00213940
• UNSPSC Code: 51111800
• PubChem Substance ID: 329815169
• NACRES: NA.32

Properties

• Product Name: HOE 140, ≥94%
• Quality Level: 200
• Assay: ≥94%
• storage temp.: −20°C
• SMILES string: N[C@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N2C[C@H](O)C[C@H]2C(=O)NCC(=O)N[C@@H](Cc3cccs3)C(=O)N[C@@H](CO)C(=O)N4Cc5ccccc5C[C@@H]4C(=O)N6[C@H]7CCCC[C@H]7C[C@H]6C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
• InChI: 1S/C59H89N19O13S/c60-37(14-5-19-67-57(61)62)48(82)72-38(15-6-20-68-58(63)64)52(86)75-22-8-18-43(75)54(88)77-30-35(80)26-44(77)50(84)70-28-47(81)71-40(27-36-13-9-23-92-36)49(83)74-41(31-79)53(87)76-29-34-12-2-1-10-32(34)24-46(76)55(89)78-42-17-4-3-11-33(42)25-45(78)51(85)73-39(56(90)91)16-7-21-69-59(65)66/h1-2,9-10,12-13,23,33,35,37-46,79-80H,3-8,11,14-22,24-31,60H2,(H,70,84)(H,71,81)(H,72,82)(H,73,85)(H,74,83)(H,90,91)(H4,61,62,67)(H4,63,64,68)(H4,65,66,69)/t33-,35+,37+,38-,39-,40-,41-,42-,43-,44-,45-,46+/m0/s1
• InChI key: QURWXBZNHXJZBE-SKXRKSCCSA-N
• Gene Information: human ... BDKRB2(624) ; mouse ... BDKRB2(12062) ; rat ... BDKRB2(25245)

Description

Amino Acid Sequence

Arg-Arg-Pro-Hyp-Gly-Thi-Ser-Tic-Oic-Arg

Biochem/physiol Actions

B₂ bradykinin receptors are present in the sensory neurons. Activation of B₂ receptor by bradykinin is associated with pro-inflammatory, pain producing and cardiovascular responses. HOE-140 is a selective B₂ bradykinin receptor antagonist. Presence of HOE-140 suppresses the effects of bradykinin and has been shown to have anti-hyperalgesic response, particularly towards inflammatory pain.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves