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H4914

Sigma-Aldrich

Honokiol

≥98% (HPLC), powder

Synonym(s):

5,3′-Diallyl-2,4′-dihydroxybiphenyl, NSC 293100

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10 MG
₹17,534.00
25 MG
₹35,046.00

About This Item

Empirical Formula (Hill Notation):
C18H18O2
CAS Number:
35354-74-6
Molecular Weight:
266.33
MDL number:
MFCD00016674
UNSPSC Code:
12352200
PubChem Substance ID:
24724501
NACRES:
NA.77

₹17,534.00

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

solubility

DMSO: 36 mg/mL

antibiotic activity spectrum

Gram-positive bacteria
neoplastics

Mode of action

DNA synthesis | interferes

storage temp.

2-8°C

SMILES string

Oc1ccc(cc1CC=C)-c2cc(CC=C)ccc2O

InChI

1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2

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This Item
38462042612Y0001290
Honokiol ≥98% (HPLC), powder

H4914

Honokiol

Honokiol A biphenyl neolignan and an active principle of Magnolia extract that displays anti-angiogenic, anti-tumor and anxiolytic properties.

384620

Honokiol

Honokiol analytical standard

42612

Honokiol

Honokiol European Pharmacopoeia (EP) Reference Standard

Y0001290

Honokiol

form

powder

form

solid

form

-

form

-

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98.0% (HPLC)

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 36 mg/mL

solubility

DMSO: 10 mg/mL, ethanol: soluble

solubility

-

solubility

-

storage condition

desiccated

storage condition

OK to freeze, protect from light

storage condition

-

storage condition

-

General description

Honokiol exhibits analgesic, antithrombotic, antispasmodic, antidepressant, antimicrobial and neuroprotective effects.[1] It regulates gamma-aminobutyric acid (GABA) A receptors.[2] Honokiol is associated with an increased risk of bleeding.[3] It prevents platelet aggregation, protects myocardium from ischemic damage and inhibits ventricular arrhythmia.[4]

Application

Honokiol has been used:
  • to study its effects on plasmid hSirt3102-399 deacetylation activity[5]
  • as an antioxidant to study its cytoprotective role in human ovarian cancer cells (SKOV-3) and Chinese hamster ovary cells (CHOK1)[6]
  • to explore its effects on oxidative stress and mitochondrial dysfunction via a sirt3-dependent manner[7]
  • for intracerebroventricular (ICV) cannulation[8][9]

Biochem/physiol Actions

Honokiol is a natural biphenyl neolignan from magnolia extract. It is antiangiogenic, antitumor, and anxiolytic.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictograms

CorrosionEnvironment
GHS05,GHS09

Signal Word

Danger

Hazard Statements

H318,H411

Hazard Classifications

Aquatic Chronic 2 - Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Certificates of Analysis (COA)

    Lot/Batch Number
    066M4759V
    105M4740V
    074M4709V
    123M4736V
    092M4730V

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    Atanas G Atanasov et al.
    Biochimica et biophysica acta, 1830(10), 4813-4819 (2013-07-03)
    Peroxisome proliferator-activated receptor gamma (PPARγ) agonists are clinically used to counteract hyperglycemia. However, so far experienced unwanted side effects, such as weight gain, promote the search for new PPARγ activators. We used a combination of in silico, in vitro, cell-based
    The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABAA receptors
    Alexeev M, et al.
    Neuropharmacology, 62(8), 2507-2514 (2012)
    Mitochondrial dynamics mediated by mitofusin 1 is required for POMC neuron glucose-sensing and insulin release control
    Ramirez S, et al.
    Cell Metabolism, 25(6), 1390-1399 (2017)
    The role of phospholipase D in modulating the MTOR signaling pathway in polycystic kidney disease
    Liu Y, et al.
    PLoS ONE, 8(8), e73173-e73173 (2013)
    Sirt3 ameliorates oxidative stress and mitochondrial dysfunction after intracerebral hemorrhage in diabetic rats
    Zheng J, et al.
    Frontiers in Neuroscience, 12, 526376-526376 (2018)
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    NF-κB and Inflammation

    Chronic inflammation is an underlying factor in the development and progression of many of the chronic diseases of aging, such as arthritis, atherosclerosis, diabetes, and cancer.

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    Discover Bioactive Small Molecules for Apoptosis

    Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of multicellular organisms, apoptosis is tightly regulated through two principal pathways by a number of regulatory and effector molecules.

    Discover Bioactive Small Molecules for Cell Cycle Research

    n proliferating cells, the cell cycle consists of four phases. Gap 1 (G1) is the interval between mitosis and DNA replication that is characterized by cell growth. Replication of DNA occurs during the synthesis (S) phase, which is followed by a second gap phase (G2) during which growth and preparation for cell division occurs. Together, these three stages comprise the interphase phase of the cell cycle. Interphase is followed by the mitotic (M) phase.

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