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F6625

Sigma-Aldrich

Flavin adenine dinucleotide disodium salt hydrate

≥95% (HPLC), powder

Synonym(s):

FAD, FAD-Na2, Riboflavin 5′-adenosine diphosphate disodium salt, FAD-Na2

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₹3,608.00

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10 MG
₹3,608.00

About This Item

Empirical Formula (Hill Notation):
C27H31N9Na2O15P2 · xH2O
CAS Number:
84366-81-4
Molecular Weight:
829.51 (anhydrous basis)
Beilstein:
5326842
MDL number:
MFCD08277021
UNSPSC Code:
41106305
PubChem Substance ID:
24894909
NACRES:
NA.51

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biological source

microbial

Quality Level

200

Assay

≥95% (HPLC)

form

powder

color

yellow to orange-brown

solubility

H2O: soluble-50 mg/mL, clear, slightly orang to deep orange

storage temp.

−20°C

SMILES string

[Na+].[Na+].[H]O[H].Cc1cc2N=C3C(=O)NC(=O)N=C3N(C[C@H](O)[C@H](O)[C@H](O)COP([O-])(=O)OP([O-])(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n5cnc6c(N)ncnc56)c2cc1C

InChI

1S/C27H33N9O15P2.2Na.H2O/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36;;;/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43);;;1H2/q;2*+1;/p-2/t14-,15+,16+,19-,20+,21+,26+;;;/m0.../s1

InChI key

GXTPHHZYFMAGLX-UJXBNFGUSA-L

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1 of 4

This Item
F8384N6660N0632
Flavin adenine dinucleotide disodium salt hydrate ≥95% (HPLC), powder

F6625

Flavin adenine dinucleotide disodium salt hydrate

Flavin adenine dinucleotide disodium salt hydrate suitable for cell culture, BioReagent

F8384

Flavin adenine dinucleotide disodium salt hydrate

β-Nicotinamide adenine dinucleotide, reduced disodium salt ~98%, pkg of 0.2 mg (per vial)

N6660

β-Nicotinamide adenine dinucleotide, reduced disodium salt

β-Nicotinamide adenine dinucleotide sodium salt

N0632

β-Nicotinamide adenine dinucleotide sodium salt

assay

≥95% (HPLC)

assay

≥95%

assay

~98%

assay

≥95% (HPLC), ≥95% (enzymatic), ≥95% (spectrophotometric assay)

solubility

H2O: soluble-50 mg/mL, clear, slightly orang to deep orange

solubility

water: 50 mg/mL, clear

solubility

-

solubility

H2O: soluble-50 mg/mL, clear, colorless to faintly yellow

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

biological source

microbial

biological source

bovine milk

biological source

-

biological source

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

storage temp.

−20°C

color

yellow to orange-brown

color

-

color

-

color

-

General description

Flavin adenine dinucleotide disodium salt hydrate (FAD-Na2) is an adenine-containing enzymatic redox cofactor[1]. Also known as flavin cofactors, FAD is critical electron transporter in living systems.[2] They catalyze several 1-2 electron redox reactions. e.g., β-oxidation of fatty acids occurs in the presence of FAD as a cofactor.[3] FAD is one of the two active coenzymes of vitamin B12(riboflavin).[4] FAD displays a significantly shorter excited state lifetime in aqueous solutions than its analog, flavin mononucleotide.[2]

Application

FAD is used to remove reactive oxygen species (ROS) from mammalian cells. The fluorescence mechanism of FAD is used to study energy-dependent intramitochondrial redox potential.[5] FAD is used as a predominant fluorophore to study unstained eosinophils, which exhibit autofluorescence compared to other leucocytes.[6]
Flavin adenine dinucleotide (FAD) is used as a redox cofactor (electron carrier) by flavoproteins including succinate dehydrogenase (complex), α-ketoglutarate dehydrogenase, apoptosis-inducing factor 2 (AIF-M2, AMID), folate/FAD-dependent tRNA methyltransferases, and N-hydroxylating flavoprotein monooxygenases. FAD is a component of the pyruvate dehydrogenase complex.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    SLCH0808
    SLCH2518
    SLCG2996
    SLCD4326
    SLCD6122

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    NADH, Disodium Salt

    Riboflavin A water soluble vitamin involved in the synthesis of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). Provides protection against oxidative damage.

    Millipore

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    Riboflavin (B2) analytical standard

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    João L Lagarto et al.
    Sensors (Basel, Switzerland), 19(12) (2019-06-16)
    Single Photon Avalanche Diode (SPAD) arrays are increasingly exploited and have demonstrated potential in biochemical and biomedical research, both for imaging and single-point spectroscopy applications. In this study, we explore the application of SPADs together with fiber-optic-based delivery and collection
    Quan Liu et al.
    Medical physics, 36(10), 4819-4829 (2009-11-26)
    Hemoglobin concentration and oxygenation in tissue are important biomarkers that are useful in both research and clinical diagnostics of a wide variety of diseases such as cancer. The authors aim to develop simple ratiometric method based on the spectral filtering
    Irina O Vvedenskaya et al.
    Molecular cell, 70(3), 553-564 (2018-04-24)
    Nucleoside-containing metabolites such as NAD+ can be incorporated as 5' caps on RNA by serving as non-canonical initiating nucleotides (NCINs) for transcription initiation by RNA polymerase (RNAP). Here, we report CapZyme-seq, a high-throughput-sequencing method that employs NCIN-decapping enzymes NudC and
    A N Mayeno et al.
    Journal of leukocyte biology, 51(2), 172-175 (1992-02-01)
    Unstained human eosinophils exhibit marked autofluorescence in comparison to other leukocytes due to a granule-associated fluorescent substance. Fluorescence spectroscopy of granule extracts reveals excitation maxima at approximately 380 and approximately 450 nm with a single emission at approximately 520, characteristic
    J Rösner et al.
    Journal of microscopy, 264(2), 215-223 (2016-07-02)
    Dynamic alterations in flavin adenine dinucleotide (FAD) fluorescence permit insight into energy metabolism-dependent changes of intramitochondrial redox potential. Monitoring FAD fluorescence in living tissue is impeded by photobleaching, restricting the length of microfluorimetric recordings. In addition, photodecomposition of these essential
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