L109

Lorglumide sodium salt

solid

• Synonym(s): (±)-4-[(3,4-Dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxopentanoic acid sodium salt, CR 1409
• Empirical Formula (Hill Notation): C₂₂H₃₁Cl₂N₂NaO₄
• CAS Number: 1021868-76-7
• Molecular Weight: 481.39
• MDL number: MFCD00083183
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278098
• NACRES: NA.32

Properties

• form: solid
• Quality Level: 100
• color: white
• solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >10 mg/mL; H₂O: 10 mg/mL; methanol: 28 mg/mL
• SMILES string: [Na+].CCCCCN(CCCCC)C(=O)C(CCC([O-])=O)NC(=O)c1ccc(Cl)c(Cl)c1
• InChI: 1S/C22H32Cl2N2O4.Na/c1-3-5-7-13-26(14-8-6-4-2)22(30)19(11-12-20(27)28)25-21(29)16-9-10-17(23)18(24)15-16;/h9-10,15,19H,3-8,11-14H2,1-2H3,(H,25,29)(H,27,28);/q;+1/p-1
• InChI key: JCNPYMDDOUQTBK-UHFFFAOYSA-M
• Gene Information: human ... CCKAR(886)

Description

Application

Lorglumide sodium salt has been used as a cck-a (cholecystokinin A) receptor antagonist for peptide determination in rat islet cells. It has been used as a CCK1 inhibitor to check the effect of cck1 (cck-a) and cck2 (cck-b) receptors on cerulein-induced upregulation of egr-1 (early growth response 1) expression in rat pancreatic acinar cells.

Biochem/physiol Actions

Potent and selective non-peptide cholecystokinin (CCK_A) receptor antagonist; orally active.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves