M4199

Myelin Oligodendrocyte Glycoprotein (40-54), Rat, Mouse

lyophilized powder

• Synonym(s): MOG (40-54)
• Empirical Formula (Hill Notation): C₈₄H₁₂₇N₂₇O₂₁
• CAS Number: 507233-87-6
• Molecular Weight: 1851.08
• UNSPSC Code: 12352202
• NACRES: NA.32

Properties

• biological source: rat
• Quality Level: 200
• Assay: ≥97% (HPLC)
• form: lyophilized powder
• color: white
• solubility: deionized water: soluble
• UniProt accession no.: Q61885; Q63345
• storage temp.: −20°C
• Gene Information: mouse ... Mog(17441) ; rat ... Mog(24558)

Description

Amino Acid Sequence

Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly

Biochem/physiol Actions

The 21-residue peptide MOG 35-55 contains an antigenic epitope responsible for the activation of CD8 encephalitogenic T cells in mice. Two truncated peptides, MOG 40-54 and MOG 44-54 were shown to bind the recombinant H-2Db protein. This complex then binds MOG specific CD8 T cells. While MOG 40-54 retained the full capability of inducing paralytic disease, MOG 44-54 only partialy causes clinical paralysis and central nervous system inflamation.

Physical form

Lyophilized from 0.1% aqueous TFA.

Other Notes

Lyophilized from 0.1% TFA in H2O

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable