M6449

MART-1 (26-35), Human

lyophilized powder

• Synonym(s): Antigen LB39-AA (26-35) (human), Antigen SK29-AA (26-35) (human), Melan-A Protein (26-35) (human), Melanoma Antigen Recognized By T-Cells 1 (26-35) (human)
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• form: lyophilized powder
• Quality Level: 200
• color: white
• solubility: water, double-distilled: soluble
• storage temp.: −20°C

Description

Amino Acid Sequence

Glu-Ala-Ala-Gly-Ile-Gly-Ile-Leu-Thr-Val

General description

Melanoma-associated antigen recognized by T cells-1 (MART-1), also known as Melan-A, is encoded by the gene mapped to human chromosome 9p24.1. The encoded protein is a hydrophobic transmembrane protein. MART-1 is mainly expressed in skin and retinae melanocytes.

The peptide represents amino acids 26-35 of MART-1 protein that is the melanoma antigen recognized by T cells. This peptide mimics the natural epitope that is presented by T cells in humans with reactivity to melanoma cells.

Biochem/physiol Actions

Melanoma-associated antigen recognized by T cells-1 (MART-1) is essential for the functioning of glycoprotein-100 (gp100). Overexpression of the gene has been observed in cutaneous melanoma (CM). In addition, deletion of Mart-1 gene leads to parotid metastatic melanoma.

Physical form

Lyophilized from 0.1% aqueous TFA

Other Notes

Lyophilized from 0.1% TFA in H2O

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable