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N7537

Sigma-Aldrich

NSC 663284

≥98% (HPLC), solid

Synonym(s):

6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione

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1 G
MYR 1,625.00

About This Item

Empirical Formula (Hill Notation):
C15H16ClN3O3
CAS Number:
383907-43-5
Molecular Weight:
321.76
MDL number:
MFCD08276924
UNSPSC Code:
12352200
PubChem Substance ID:
24724556
NACRES:
NA.77

MYR 1,625.00

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Quality Level

100

Assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

red

solubility

DMSO: ≥10 mg/mL
H2O: insoluble

storage temp.

2-8°C

SMILES string

ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O

InChI

1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2

InChI key

BMKPVDQDJQWBPD-UHFFFAOYSA-N

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Show Differences

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This Item
N1537C127S8822
NSC 663284 ≥98% (HPLC), solid

N7537

NSC 663284

NU7026 ≥98% (HPLC), solid

N1537

NU7026

CNQX ≥98% (HPLC), solid

C127

CNQX

SB-525334 ≥98% (HPLC)

S8822

SB-525334

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

solid

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

solubility

DMSO: ≥10 mg/mL, H2O: insoluble

solubility

DMSO: soluble 3 mg/mL at 60 °C, H2O: insoluble

solubility

DMSO: >10 mg/mL, H2O: insoluble

solubility

DMSO: ≥20 mg/mL

storage condition

protect from light

storage condition

-

storage condition

protect from light

storage condition

-

Application

NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation.[1] It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.[2]

Biochem/physiol Actions

NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.[3]
Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

470.1 °F

Flash Point(C)

243.4 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Certificates of Analysis (COA)

    Lot/Batch Number
    056M4608V
    020M4612V
    020M4612
    095K4606

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    Bulletin of the World Health Organization, 92(7), 490-498 (2014-08-12)
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    The Journal of thoracic and cardiovascular surgery, 149(4), 1194-1202 (2015-01-18)
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    American journal of respiratory and critical care medicine, 188(7), 807-812 (2013-08-10)
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