N1537

NU7026

≥98% (HPLC), solid

• 동의어(들): 2-(Morpholin-4-yl)-benzo[h]chromen-4-one
• 실험식(Hill 표기법): C₁₇H₁₅NO₃
• CAS Number: 154447-35-5
• Molecular Weight: 281.31
• MDL number: MFCD06798345
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329818582
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 색상: tan
• solubility: DMSO: soluble 3 mg/mL at 60 °C; H₂O: insoluble
• 배송 상태: wet ice
• 저장 온도: 2-8°C
• SMILES string: O=C1C=C(Oc2c1ccc3ccccc23)N4CCOCC4
• InChI: 1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2
• InChI key: KKTZALUTXUZPSN-UHFFFAOYSA-N

설명

애플리케이션

NU7026 has been used:

• as a DNA-dependent protein kinase (DNA-PK) inhibitor, to pre-treat colon cancer cell
• in kinase inhibitor experiments for treating zygotes with visible pronuclei post 20 h-human chorionic gonadotropin (hCG)
• to determine its influence on cytotoxicity of dibenzo[def,p]chrysene on HepG2 cells

Potent, ATP-competitive. IC₅₀ = 0.23 μM. Selectivity over other PI3K-related kinases (IC₅₀ = 13 μM for PI3K and >100 μM for ATM and ATR).

생화학적/생리학적 작용

Cell permeable, small molecule benzochromenone inhibitor of DNA-PK (DNA dependent protein kinase).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)