N7764

Nicotinic acid mononucleotide

• Synonym(s): Nicotinate mononucleotide
• Empirical Formula (Hill Notation): C₁₁H₁₄NO₉P
• CAS Number: 321-02-8
• Molecular Weight: 335.20
• MDL number: MFCD00070358
• UNSPSC Code: 12352106
• PubChem Substance ID: 24897839
• NACRES: NA.79

Properties

• biological source: animal
• Quality Level: 200
• Assay: ≥98.0% (HPLC)
• form: powder
• technique(s): HPLC: suitable
• color: white
• storage temp.: −20°C
• SMILES string: OC1C(O)C(OC1COP(O)(O)=O)[N]2=CC(=CC=C2)C(O)=O
• InChI: 1S/C11H15NO9P/c13-8-7(5-20-22(17,18)19)21-10(9(8)14)12-3-1-2-6(4-12)11(15)16/h1-4,7-10,13-14H,5H2,(H,15,16)(H2,17,18,19)
• InChI key: IUJWGLOJJKFASX-UHFFFAOYSA-N

Description

General description

Nicotinic acid mononucleotide (NaMN) is formed from nicotinic acid 5-phosphoribosyl-1-pyrophosphate (PRPP) in the Preiss-Handler pathway in the presence of enzyme phosphoribosyltransferase (NaPRT).

Application

Nicotinic acid mononucleotide has been used as a substrate for NMN/NaMN adenylyltransferase (NMNAT) during nicotinamide adenine dinucleotide (NAD) biosynthesis.

Biochem/physiol Actions

Nicotinic acid mononucleotide (NaMN) may be used to study the relationship between the phosphate-responsive signaling (PHO) pathway and nicotine adenine dinucleotide (NAD(+)) metabolism in yeast. Nicotinate mononucleotide is a substrate for NMN/NaMN adenylyltransferase (NMNAT) and nicotinate mononucleotide adenylyltransferase. NaMN amidation results in the synthesis of nicotinamide mononucleotide(NMN), which is further converted to NAD cofactor.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves