O100

Oxotremorine M

solid

• Synonym(s): N,N,N,-Trimethyl-4-(2-oxo-1-pyrrolidinyl)-2-butyn-1-ammonium iodide, Oxotremorine methiodide
• Empirical Formula (Hill Notation): C₁₁H₁₉IN₂O
• CAS Number: 63939-65-1
• Molecular Weight: 322.19
• MDL number: MFCD00055133
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277861
• NACRES: NA.77

Properties

• form: solid
• color: white
• solubility: H₂O: 24 mg/mL; ethanol: 4.6 mg/mL
• storage temp.: 2-8°C
• SMILES string: [I-].C[N+](C)(C)CC#CCN1CCCC1=O
• InChI: 1S/C11H19N2O.HI/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14;/h6-10H2,1-3H3;1H/q+1;/p-1
• InChI key: VVLMSCJCXMBGDI-UHFFFAOYSA-M
• Gene Information: human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

Description

Application

Oxotremorine M has been used as a muscarinic acetylcholine receptor (mAchR) agonist:

• to study its acute effects on the movement of Caenorhabditis elegans
• to treat hippocampal neurons for studying fibroblast growth factor receptor 1 (FGFR1) phosphorylation
• to induce bladder overactivity in rats

Biochem/physiol Actions

Oxotremorine M is a nonselective muscarinic acetylcholine receptor agonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) and Acetylcholine Receptors (Nicotinic) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H300 + H310 + H330
• Precautionary Statements: P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves