O2875

Orotic acid potassium salt

≥98%

• Synonym(s): 6-Carboxy-2,4-dihydroxypyrimidine, Uracil-6-carboxylic acid
• Linear Formula: C₅H₃N₂O₄K
• CAS Number: 24598-73-0
• Molecular Weight: 194.19
• EC Number: 246-341-0
• MDL number: MFCD00039118
• UNSPSC Code: 41106305
• PubChem Substance ID: 24897970
• NACRES: NA.51

Properties

• Quality Level: 200
• Assay: ≥98%
• form: powder
• solubility: 1 M NaOH: 25 mg/mL, clear to slightly hazy, colorless to faintly yellow
• SMILES string: [K+].[O-]C(=O)C1=CC(=O)NC(=O)N1
• InChI: 1S/C5H4N2O4.K/c8-3-1-2(4(9)10)6-5(11)7-3;/h1H,(H,9,10)(H2,6,7,8,11);/q;+1/p-1
• InChI key: DHBUISJCVRMTAZ-UHFFFAOYSA-M

Description

Application

Orotic acid (OA) is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5′-phospho-α-d-ribose 1′-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5′-monophosphate (OMP). Orotic acid is used as a starting material for the potential commercial bioproduction of uridine 5′-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. OA may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves