P0043

PNU-120596

≥98% (HPLC)

• Synonym(s): N-(5-Chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea, NSC 216666
• Empirical Formula (Hill Notation): C₁₃H₁₄ClN₃O₄
• CAS Number: 501925-31-1
• Molecular Weight: 311.72
• MDL number: MFCD00095313
• UNSPSC Code: 12352200
• PubChem Substance ID: 329819995
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• color: white to off-white
• solubility: DMSO: >10 mg/mL
• storage temp.: room temp
• SMILES string: O=C(NC1=NOC(C)=C1)NC2=CC(Cl)=C(OC)C=C2OC
• InChI: 1S/C13H14ClN3O4/c1-7-4-12(17-21-7)16-13(18)15-9-5-8(14)10(19-2)6-11(9)20-3/h4-6H,1-3H3,(H2,15,16,17,18)
• InChI key: CEIIEALEIHQDBX-UHFFFAOYSA-N

Description

Biochem/physiol Actions

An allosteric modulator of α7 nicotinic receptors, N-(5-chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholinePNU-120596 is a positive allosteric modulator selective for the α7 nicotinic acetylcholine receptor. PNU-120596 produces no detectable change in currents mediated by α4β2, α3β4, α9α10 nAChRs. It increases channel mean open time, but does not affect ion selectivity. It does not bind at the agonist binding site, but induces conformational changes similar to the natural effector.

PNU-120596 is a positive allosteric modulator of the α7 nicotinic acetylcholine receptor.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable