P4904

Platelet Activating Factor-16

≥98%

• Synonym(s): 1-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine, 1-O-Palmityl-2-acetyl-sn-glycero-3-phosphocholine monohydrate, 2-Acetyl-1-hexadecyl-sn-glycero-3-phosphocholine, 3-sn-Phosphatidylcholine, 1-hexadecyl-2-acetyl, PAF(C₁₆), Platelet activating factor
• Empirical Formula (Hill Notation): C₂₆H₅₄NO₇P · xH₂O
• CAS Number: 74389-68-7
• Molecular Weight: 523.68 (anhydrous basis)
• Beilstein: 3574588
• MDL number: MFCD00150679
• UNSPSC Code: 12352211
• PubChem Substance ID: 24898570
• NACRES: NA.77

Properties

• Product Name: β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine hydrate, ≥98%
• Quality Level: 200
• Assay: ≥98%
• form: powder
• storage temp.: −20°C
• SMILES string: O.CCCCCCCCCCCCCCCCOC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(C)=O
• InChI: 1S/C26H54NO7P.H2O/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5;/h26H,6-24H2,1-5H3;1H2/t26-;/m1./s1
• InChI key: HFMSDOHEENWULV-UFTMZEDQSA-N

Description

Application

β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine has been used:

• to study its effects on phagocytic activity and production of superoxide anion in equine alveolar macrophage and blood neutrophils
• to study its protective effects against cisplatin-induced cell death in a human melanoma cell line in vitro
• to determine its effects on cervical ripening and leukocyte infiltration in rat models

Biochem/physiol Actions

β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine or platelet-activating factor (PAF), is a phospholipid, and a pro-inflammatory lipid mediator. It acts as a ligand for G protein-coupled platelet-activating factor (PAF) receptors and participates in several biological processes such as airway constriction, hypotension, platelet activation, and increased vascular permeability. PAF is released by various cells such as platelets, neutrophils, endothelial cells, and monocytes/macrophages. The levels of PAF are low in the blood due to its rapid metabolism by PAF acetylhydrolase and low production.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves