S179

R(+)-SKF-81297 hydrobromide

≥98% (HPLC), solid

• Synonym(s): R-(+)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide
• Empirical Formula (Hill Notation): C₁₆H₁₆ClNO₂ · HBr
• CAS Number: 253446-15-0
• Molecular Weight: 370.67
• MDL number: MFCD00671792
• UNSPSC Code: 12352200
• PubChem Substance ID: 24899496
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• optical activity: [α]22/D +15.14°, c = 0.52 in DMF(lit.)
• storage condition: desiccated; protect from light
• color: white to off-white
• solubility: H₂O: 6 mg/mL; DMSO: soluble
• SMILES string: Br[H].Oc1cc2[C@H](CNCCc2c(Cl)c1O)c3ccccc3
• InChI: 1S/C16H16ClNO2.BrH/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20;/h1-5,8,13,18-20H,6-7,9H2;1H/t13-;/m1./s1
• InChI key: RMIJGBMRNYUZRG-BTQNPOSSSA-N

Description

Application

R(+)-SKF-81297 hydrobromide has used as D1-type dopamine receptor agonist:

• to test it effect on the spike firing in rat retinal ganglion cells
• in human embryonic kidney (HEK) 293T cells
• to test its inhibitory effect in microglial cells

Biochem/physiol Actions

SKF-81297 administration in spontaneously hypertensive rats (SHR) induces an increase in expression of proto-oncogene c-fos mRNA leading to biphasic effect on locomotion. It favors the turnover of phosphoinositide and adenylyl cyclase. SKF-81297 is involved in the stimulation of neurons, in particular the postsynaptic striatal neurons.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves