S3445

SM-19712 hydrate

≥98% (HPLC)

• Synonym(s): 4-Chloro-N-[[(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino]carbonyl]benzenesulfonamide sodium salt hydrate
• Empirical Formula (Hill Notation): C₁₈H₁₃ClN₅NaO₃S · xH₂O
• CAS Number: 194542-56-8
• Molecular Weight: 437.84 (anhydrous basis)
• MDL number: MFCD06798351
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824532
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: off-white to light brown
• solubility: DMSO: ≥20 mg/mL; H₂O: ≥20 mg/mL
• storage temp.: 2-8°C
• SMILES string: ClC1=CC=C(S(N(C(NC2=C(C#N)C(C)=NN2C3=CC=CC=C3)=O)[Na])(=O)=O)C=C1
• InChI: 1S/C12H10ClN5O3S.Na.H2O/c1-7-10(6-14)11(17-16-7)15-12(19)18-22(20,21)9-4-2-8(13)3-5-9;;/h2-5H,1H3,(H3,15,16,17,18,19);;1H2/q;+1;/p-1
• InChI key: HLHPDQXMLDUDQV-UHFFFAOYSA-M

Description

Application

SM-19712 hydrate was used in studies to determine the effectiveness of ECE inhibition as a treatment option for Alzheimer′s disease.

Biochem/physiol Actions

Nonpeptide, potent and selective endothelin converting enzyme inhibitor.

SM-19712 a sulfonylureid-pyrazole derivative is a potent and selective inhibitor of endothelin converting enzyme (ECE). It attenuates the effects of ischemic acute renal failure and reduces the inflammation, tissue injury and vasoconstriction induced by dextran sodium sulfate in mouse colon.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves