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Key Documents

S5576

Sigma-Aldrich

SKA-31

≥98% (HPLC)

Synonym(s):

Naphtho[1,2-d]thiazol-2-ylamine

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About This Item

Empirical Formula (Hill Notation):
C11H8N2S
CAS Number:
Molecular Weight:
200.26
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.25

Quality Level

Assay

≥98% (HPLC)

form

solid

solubility

DMSO: ≥30 mg/mL

storage temp.

−20°C

SMILES string

Nc1nc2c(ccc3ccccc23)s1

InChI

1S/C11H8N2S/c12-11-13-10-8-4-2-1-3-7(8)5-6-9(10)14-11/h1-6H,(H2,12,13)

InChI key

FECQXVPRUCCUIL-UHFFFAOYSA-N

Biochem/physiol Actions

SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels.
SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC50 is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice, suggesting potassium channel activation as a therapeutic target for hypertension.
SKA31 is an activator of KCa2 and KCa3.1
SKA31 is an activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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