S7809

SKF-96365

≥98% (HPLC), solid

• Synonym(s): 1-[β-(3-(4-Methoxyphenyl)propoxy)-4-methoxyphenethyl]-1H-imidazole hydrochloride, 1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole
• Empirical Formula (Hill Notation): C₂₂H₂₆N₂O₃ · HCl
• CAS Number: 130495-35-1
• Molecular Weight: 402.91
• MDL number: MFCD00236407
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278710
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: DMSO: >20 mg/mL; H₂O: >20 mg/mL
• SMILES string: Cl.COc1ccc(CCCOC(Cn2ccnc2)c3ccc(OC)cc3)cc1
• InChI: 1S/C22H26N2O3.ClH/c1-25-20-9-5-18(6-10-20)4-3-15-27-22(16-24-14-13-23-17-24)19-7-11-21(26-2)12-8-19;/h5-14,17,22H,3-4,15-16H2,1-2H3;1H
• InChI key: FWLPKVQUECFKSW-UHFFFAOYSA-N

Description

Application

SKF-96365 has been used as :

• a nonselective transient receptor potential 6 (TRPC6) blocker in human podocytes
• an antagonist of store-operated Ca²⁺ influx in neurons
• an inhibitor for transient receptor potential 3 (TRPC3) in mice

Biochem/physiol Actions

SKF-96365 with an alkylated imidazole ring is a selective inhibitor of receptor-mediated Ca²⁺ entry and voltage-gated Ca²⁺ entry . SKF-96365 mediated depolarization of smooth cardiac muscle membrane and had no impact on the acetylcholine (ACh)-induced depolarization. It is an inhibitor for SOCE (store-operated calcium entry). It also inhibits Homer1 protein expression. SKF-96365 elicits protective functionality in 1-methyl-4-phenylpyridinium(MPP) mediated cytotoxicity.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves