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SAB4300587

Sigma-Aldrich

Anti-JAK2 (Ab-570) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-JTK10 antibody produced in rabbit, Anti-Janus kinase 2 (a protein tyrosine kinase) antibody produced in rabbit

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589,00 $

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100 μG
589,00 $

About This Item

UNSPSC Code:
12352203
NACRES:
NA.43

589,00 $

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~125 kDa

species reactivity

rat, human

concentration

1 mg/mL

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Anti-JAK2 (Ab-570) antibody produced in rabbit affinity isolated antibody

SAB4300587

Anti-JAK2 (Ab-570) antibody produced in rabbit

Anti-phospho-JAK2 (pTyr1007) antibody produced in rabbit affinity isolated antibody

SAB4300124

Anti-phospho-JAK2 (pTyr1007) antibody produced in rabbit

Anti-JAK2 antibody produced in rabbit affinity isolated antibody

SAB4501602

Anti-JAK2 antibody produced in rabbit

Anti-PTK2 (Ab-576/577) antibody produced in rabbit affinity isolated antibody

SAB4300597

Anti-PTK2 (Ab-576/577) antibody produced in rabbit

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100, western blot: 1:500-1:1000

technique(s)

ELISA: 1:5000, immunohistochemistry: 1:50-1:100

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100, western blot: 1:500-1:1000

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

General description

JAK2 (janus kinase 2) encodes a tyrosine kinase. It belongs to the the Jak family of protein. It is located on chromosome 9p24.

Immunogen

Peptide sequence around aa. 568-572 (G-D-Y-G-Q), according to the protein JAK2.

Biochem/physiol Actions

JAK2 (janus kinase 2) plays an important role in the activities of cytokines receptors. Overexpression of JAK2 results in neuroblastoma. JAK2 mutations promote primary resistance to PD-1 (anti-programmed death protein 1) blockade therapy.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Plays a role in leptin signaling and control of body weight.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    951421522

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    Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2
    Joos S, et al.
    International Journal of Cancer. Journal International Du Cancer, 103(4), 489-495 (2003)
    Jak2 is essential for signaling through a variety of cytokine receptors
    Parganas E, et al.
    Cell, 93(3), 385-395 (1998)
    Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells.
    Borriello L
    Cancer Research, 77(18), 5142-5157 (2017)
    Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.
    Shin DS
    Cancer Discovery, 7(2), 188-201 (2017)
    Lin Miao et al.
    Cancer immunology, immunotherapy : CII, 63(7), 699-711 (2014-04-11)
    Gastric cancer remains the second leading cause of cancer-related deaths worldwide. Although Helicobacter pylori (H. pylori) is considered to be a critical risk factor, the molecular mechanisms underlying H. pylori-induced gastric carcinogenesis are still poorly defined. Recently, accumulating studies have
    View All Related Papers

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