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SBR00011

Sigma-Aldrich

Clarithromycin, Ready Made Solution

50 mg/mL in DMSO

Synonym(s):

6-O-methyl erythromycin

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About This Item

Empirical Formula (Hill Notation):
C38H69NO13
CAS Number:
81103-11-9
Molecular Weight:
747.95
MDL number:
MFCD00865140
UNSPSC Code:
51102829
PubChem Substance ID:
329824644
NACRES:
NA.85
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description

Ready Made Solution

Quality Level

200

form

liquid

storage condition

dry media (Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.)

concentration

50 mg/mL in DMSO

color

colorless to faint yellow

antibiotic activity spectrum

Gram-positive bacteria

Mode of action

protein synthesis | interferes

storage temp.

−20°C

SMILES string

N([C@@H]1[C@H]([C@@H](O[C@@H](C1)C)O[C@@H]2[C@H]([C@@H]([C@H](C(=O)O[C@@H]([C@]([C@@H]([C@H](C(=O)[C@@H](C[C@]2(OC)C)C)C)O)(O)C)CC)C)O[C@@H]3O[C@H]([C@@H]([C@@](C3)(OC)C)O)C)C)O)(C)C

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This Item
A0169A2576A0576
Agarose BioReagent, low EEO

A9539

Agarose

Agarose Type I-A, low EEO

A0169

Agarose

Agarose Ultra-low Gelling Temperature, molecular biology grade

A2576

Agarose

Agarose Low EEO

A0576

Agarose

EEO

0.09-0.13

EEO

0.09-0.13

EEO

≤0.12

EEO

≤0.12

form

powder

form

powder

form

powder

form

powder

gel strength

≥1200 g/cm2 (1% gel)

gel strength

≥1200 g/cm2 (1% gel)

gel strength

≥300 g/cm2 (1.5% gel)

gel strength

≥1800 g/cm2 (1% gel), ≥3200 g/cm2 (1.5% gel)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

product line

BioReagent

product line

-

product line

-

product line

-

grade

for molecular biology

grade

-

grade

Molecular Biology

grade

-

General description

Clarithromycin is a macrolide antibiotic, which has both antibacterial and anti-inflammatory actions. It is a semi-synthetic 14-membered derivative of erythromycin A, which is resistant to degradation under acidic conditions.[1][2]

Application

Clarithromycin may be used for-
  • the study of the effects of clarithromycin on rate-dependent changes in QT, Tp-e and proarrhythmic events performed on arterially perfused rabbit left ventricular wedge preparations[3]
  • the culture of parasites expressing GFP (green fluorescence protein) targeted to the apicoplast, to be further used for microscopy-based assays[4]
  • the study of the synergism of NAB741 with clarithromycin in microtiter plates.[5]

Biochem/physiol Actions

Macrolides, such as clarithromycin, prevent protein synthesis in bacteria, by binding to 50S ribosomal subunit. It also binds to other ribosomal proteins, and prevents the translocation of pepti-dyl-tRNA.[2] In patients with refractory asthma, it is capable of regulating the levels of interleukin-8 (IL-8), and neutrophil accumulation and activation in lungs. Thus, it might be used as an additional therapy in asthma to reduce noneosinophilic airway inflammation.[1]

Packaging

2ML

Storage and Stability

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

188.6 °F

Flash Point(C)

87 °C

  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    026M4056V
    11151207

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    Stephen AM and Phillips GO
    Food Sci. Technol., 160 (2006)
    Lukas Kain et al.
    Journal of the mechanical behavior of biomedical materials, 85, 225-236 (2018-06-23)
    Mechanical assessment of biological materials and tissue-engineered scaffolds is increasingly focusing at lower length scale levels. Amongst other techniques, atomic force microscopy (AFM) has gained popularity as an instrument to interrogate material properties, such as the indentation modulus, at the
    Marijn Siemons et al.
    Biomedical optics express, 11(2), 735-751 (2020-03-07)
    Single-molecule localization microscopy (SMLM) enables fluorescent microscopy with nanometric resolution. While localizing molecules close to the coverslip is relatively straightforward using high numerical aperture (NA) oil immersion (OI) objectives, optical aberrations impede SMLM deeper in watery samples. Adaptive optics (AO)
    Zita Olah et al.
    Ecotoxicology and environmental safety, 144, 115-122 (2017-06-13)
    Rotifers have been used in biological research as well-characterized models of aging. Their multi-organ characters and their sensitivity for chemicals and environmental changes make them useful as in vivo toxicological and lifespan models. Our aim was to create a bdelloid
    G Palazzolo et al.
    Scientific reports, 7(1), 8499-8499 (2017-08-19)
    The need for in vitro models that mimic the human brain to replace animal testing and allow high-throughput screening has driven scientists to develop new tools that reproduce tissue-like features on a chip. Three-dimensional (3D) in vitro cultures are emerging
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