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Key Documents

SBR00017

Sigma-Aldrich

Puromycin aminonucleoside Ready Made Solution

10 mg/mL in water

Synonym(s):

3′-Amino-3′-deoxy-N6,N6-dimethyladenosine

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About This Item

Empirical Formula (Hill Notation):
C12H18N6O3
CAS Number:
Molecular Weight:
294.31
UNSPSC Code:
51281912
NACRES:
NA.85

Assay

≥98%

Quality Level

form

liquid

concentration

10 mg/mL in water

antibiotic activity spectrum

Gram-positive bacteria
neoplastics
parasites

Mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

N[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(N(C)C)=NC=N3)O[C@@H]1CO

InChI

1S/C12H18N6O3/c1-17(2)10-8-11(15-4-14-10)18(5-16-8)12-9(20)7(13)6(3-19)21-12/h4-7,9,12,19-20H,3,13H2,1-2H3

InChI key

RYSMHWILUNYBFW-UHFFFAOYSA-N

Biochem/physiol Actions

Puromycin aminonucleoside is an aminonucleoside derivative of the known antibiotic puromycin. Puromycin aminonucleoside has been used in nephrology research, studying focal and segmental glomerulosclerosis, and in the induction of nephrosis in rats. Rats with puromycin aminonucleoside-induced nephrotic syndrome were used to study the excretion of sodium and NOx metabolites.

Puromycin aminonucleoside has also been used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability. A puromycin aminonucleoside nephrosis model of rat glomerular disease was also used to study the role of the neuron-specific ubiquitin C-terminal hydrolase protein gene product 9.5 (PGP 9.5).

Preparation Note

Puromycin aminonucleoside solution is provided at 10 mg/mL in water and could be further diluted in aqueous buffers to a working concentration of 10 μg/mL (1:1000).

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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