SML0363

DIM-C-pPhtBu

≥96% (HPLC)

• Synonym(s): 1,1-Bis(3-indolyl)-1-(p-t-butylphenyl)methane, 3,3′-[[4-(1,1-Dimethylethyl)phenyl]methylene]bis-1H-indole
• Empirical Formula (Hill Notation): C₂₇H₂₆N₂
• CAS Number: 94944-80-6
• Molecular Weight: 378.51
• EC Number: 305-658-5
• MDL number: MFCD18082348
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825365
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥96% (HPLC)
• form: powder
• storage condition: desiccated
• color: light orange to dark orange
• solubility: DMSO: >15 mg/mL
• storage temp.: −20°C
• SMILES string: CC(C)(C)c1ccc(cc1)C(c2c[nH]c3ccccc23)c4c[nH]c5ccccc45
• InChI: 1S/C27H26N2/c1-27(2,3)19-14-12-18(13-15-19)26(22-16-28-24-10-6-4-8-20(22)24)23-17-29-25-11-7-5-9-21(23)25/h4-17,26,28-29H,1-3H3
• InChI key: NCPVEZRBHNDCIV-UHFFFAOYSA-N

Description

Biochem/physiol Actions

DIM-C-pPhtBu induces apoptosis in various cancer cell lines; induces endoplasmic reticulum (ER) stress in KB cancer cells.

DIM-C-pPhtBu, similar to other C-DIMs, exhibits a broad range of anticancer and antitumorigenic activities against multiple tumor types. DIM-C-pPhtBu causes apoptotic cell death of KB cells by activation of endoplasmic reticulum stress through induction of CHOP protein that is associated with the apoptosis in human oral cancer cells. Also it appears to induce an autophagic cell death in drug-resistant ER-negative breast tumors.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable