SML0599

DIF-1

≥98% (HPLC)

• Synonym(s): 1-(3,5-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-Hexanone
• Empirical Formula (Hill Notation): C₁₃H₁₆Cl₂O₄
• CAS Number: 111050-72-7
• Molecular Weight: 307.17
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: Clc1c(c(c(c(c1O)C(=O)CCCCC)O)Cl)OC
• InChI: 1S/C13H16Cl2O4/c1-3-4-5-6-7(16)8-11(17)9(14)13(19-2)10(15)12(8)18/h17-18H,3-6H2,1-2H3
• InChI key: VUDQSRFCCHQIIU-UHFFFAOYSA-N

Description

Biochem/physiol Actions

DIF-1 (differentiation-inducing factor-1) is isolated from a Dictyostelium slime mold, and is used to inhibit proliferation/promote differentiation in various cell lines.

DIF-1 is a cell differentiation inducing factor.

DIF-1 is a cell differentiation inducing factor.
Differentiation-inducing factor-1 (DIF-1) blocks the migration and invasion of cells and decreases the expression of matrix metalloproteinase-2. It prevents the proliferation of cells using glycogen synthase kinase-3 (GSK-3)-dependent mechanism. DIF-1 is more active when compared to DIF-2 in promoting stalk cell differentiation under submerged assay conditions.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable