SML1884

Mitoglitazone

≥98% (HPLC)

• Synonym(s): 5-[[4-[2-(5-ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione, MSDC-0160
• Empirical Formula (Hill Notation): C₁₉H₁₈N₂O₄S
• CAS Number: 146062-49-9
• Molecular Weight: 370.42
• MDL number: MFCD00916084
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: CCC1=CN=C(C(COC2=CC=C(CC3SC(NC3=O)=O)C=C2)=O)C=C1
• InChI: 1S/C19H18N2O4S/c1-2-12-5-8-15(20-10-12)16(22)11-25-14-6-3-13(4-7-14)9-17-18(23)21-19(24)26-17/h3-8,10,17H,2,9,11H2,1H3,(H,21,23,24)
• InChI key: IRNJSRAGRIZIHD-UHFFFAOYSA-N

Description

Biochem/physiol Actions

MSDC-0160 is an mTOT (mitochondrial target of thiazolidinediones) modulator that targets the mitochondrial pyruvate carrier (MPC), which is a key controller of cellular metabolism. MSDC-0160 is reported to enhance the cells′ ability to handle potentially harmful proteins, which leads to reduced inflammation and less nerve cell death. It has already been in clinical trials for diabetes and Alzheimer′s disease and clinical trials for Parkinson′s Disease are planned.

Mitochondrial pyruvate carrier (MPC) inhibitor

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable