SML1916

Marizomib

≥95% (HPLC), (Salinospora tropica)

• Synonym(s): (1R,4R,5S)-4-(2-Chloroethyl)-1-[(S)-(1S)-2-cyclohexen-1-ylhydroxymethyl]-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione, NPI-0052, Salinosporamide A
• Empirical Formula (Hill Notation): C₁₅H₂₀ClNO₄
• CAS Number: 437742-34-2
• Molecular Weight: 313.78
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• biological source: (Salinospora tropica)
• Assay: ≥95% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: ClCC[C@@H]1[C@@]2(OC(=O)[C@@]2(NC1=O)[C@@H](O)[C@H]3CCCC=C3)C
• InChI: 1S/C15H20ClNO4/c1-14-10(7-8-16)12(19)17-15(14,13(20)21-14)11(18)9-5-3-2-4-6-9/h3,5,9-11,18H,2,4,6-8H2,1H3,(H,17,19)/t9-,10+,11+,14+,15+/m1/s1
• InChI key: NGWSFRIPKNWYAO-SHTIJGAHSA-N

Description

Application

Marizomib has been used as a proteasome inhibitor:

• to study its effects on glioblastoma cell lines
• to analyze its effects on the aging of killifish brain
• to test its effect on protein kinase B (PKB/AKT) levels in multiple myeloma cells

Biochem/physiol Actions

Marizomib a natural product is a marine-derived β-lactone-γ-lactam. It shows therapeutic effects against hematologic and solid tumor malignancies.. It is involved in the activation of caspase-3,-8, and -9, increases the reactive oxygen species (ROS) and promotes apoptosis. Marizomib can cross the blood-brain barrier and might have the potential to treat primary brain tumors. It possesses anti-tumor properties.

Marizomib is a second generation proteasome inhibitor with anti-cancer activity.

Marizomib is a second generation proteasome inhibitor with anti-cancer activity. Marizomib binds irreversibly and potently inhibits all three 20S proteasome subunits.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable