SML2146

SR-18292 Maleate

≥98% (HPLC)

• Synonym(s): SR-18292 Maleate, 1-[(1,1-Dimethylethyl)[(4-methylphenyl)methyl]amino]-3-(1H-indol-4-yloxy)-2-propanol maleate, SR 18292, SR 18292 maleate
• Empirical Formula (Hill Notation): C₂₃H₃₀N₂O₂ · C₄H₄O₄
• CAS Number: 2095432-55-4
• Molecular Weight: 482.57
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CC(C)(C)N(CC(O)COC1=CC=CC2=C1C=CN2)CC3=CC=C(C)C=C3.O=C(O)/C=C\C(O)=O
• InChI key: CMTOYDGVFTZNSM-BTJKTKAUSA-N

Description

Application

SR-18292 Maleate has been used as a peroxisome proliferator-activated receptor γ coactivator 1 α (PGC1α) inhibitor to study the protective effects of pioglitazone on demyelinated axons.

Biochem/physiol Actions

SR-18292 is a potent and specific inhibitor of hepatic gluconeogenesis via increased acetylation of PGC-1α and suppression of gluconeogenic gene expression. SR-18292 reduces blood glucose and increases hepatic insulin sensitivity in mouse models of T2D.

inhibitor of hepatic gluconeogenesis via increased acetylation of PGC-1α; anti-diabetic

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable