SML2440

SGC-iMLLT

≥98% (HPLC)

• Synonym(s): (S)-1-Methyl-N-(2-((2-methylpyrrolidin-1-yl)methyl)-1H-benzo[d]imidazol-5-yl)-1H-indazole-5-carboxamide, Chemical Probe 92
• Empirical Formula (Hill Notation): C₂₂H₂₄N₆O
• CAS Number: 2255338-25-9
• Molecular Weight: 388.47
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL
• storage temp.: 2-8°C
• SMILES string: O=C(C1=CC2=C(N(C)N=C2)C=C1)NC3=CC=C4NC(CN5[C@@H](C)CCC5)=NC4=C3
• InChI: 1S/C22H24N6O/c1-14-4-3-9-28(14)13-21-25-18-7-6-17(11-19(18)26-21)24-22(29)15-5-8-20-16(10-15)12-23-27(20)2/h5-8,10-12,14H,3-4,9,13H2,1-2H3,(H,24,29)(H,25,26)/t14-/m0/s1
• InChI key: QGNDVASWIHEXCL-AWEZNQCLSA-N

Description

Biochem/physiol Actions

SGC-iMLLT (Chemical Probe 92) is a cell penetrant, potent and selective inhibitor of YEATS domain MLLT1/3 histone interaction. SGC-iMLLT downregulates MYC and DDN genes, while increases CD86 in MV4;11 AML cells.

cell penetrant, potent and selective inhibitor of YEATS domain MLLT1/3 histone interaction

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable