SML2537

NSAH

≥98% (HPLC)

• Synonym(s): 2-Hydroxy-benzoic acid (2E)-2-[(2-hydroxy-1-naphthalenyl)methylene]hydrazide
• Empirical Formula (Hill Notation): C₁₈H₁₄N₂O₃
• CAS Number: 1099592-35-4
• Molecular Weight: 306.32
• MDL number: MFCD00196698
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: OC1=CC=CC=C1C(N/N=C/C2=C(C=CC=C3)C3=CC=C2O)=O
• InChI: 1S/C18H14N2O3/c21-16-8-4-3-7-14(16)18(23)20-19-11-15-13-6-2-1-5-12(13)9-10-17(15)22/h1-11,21-22H,(H,20,23)/b19-11+
• InChI key: ZZSJOLDICPVVAV-YBFXNURJSA-N

Description

Biochem/physiol Actions

NSAH is a cell penetrant, potent and selective nonnucleoside reversible inhibitor of large subunit (hRRM1) of hRR (human ribonucleotide reductase). NSAH binds to catalytic site of hRRM1. It inhibits hRR in cells. NSAH exhibit potent cytotoxicity toward cancer cells, while demonstrated very moderate toxicity against normal blood progenitor cells.

cell penetrant, potent and selective nonnucleoside reversible inhibitor of large subunit (hRRM1) of hRR (human ribonucleotide reductase)

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable