SML2642

S29434

≥98% (HPLC)

• Synonym(s): N-[2-(2-Methoxy-6H-dipyrido[2,3-a:3′,2′-e]pyrrolizin-11-yl)ethyl]-2-furancarboxamide, S 29434, [2-(2-methoxy-5H-1,4b,9-triaza(indeno[2,1-a]inden-10-yl)ethyl]-2-furamide
• Empirical Formula (Hill Notation): C₂₁H₁₈N₄O₃
• CAS Number: 874484-20-5
• Molecular Weight: 374.39
• MDL number: MFCD28160701
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: [n]21c3c(nc(cc3)OC)c(c2c5ncccc5C1)CCNC(=O)c4[o]ccc4
• InChI: 1S/C21H18N4O3/c1-27-17-7-6-15-19(24-17)14(8-10-23-21(26)16-5-3-11-28-16)20-18-13(12-25(15)20)4-2-9-22-18/h2-7,9,11H,8,10,12H2,1H3,(H,23,26)
• InChI key: XJIUMLVQBQKCJA-UHFFFAOYSA-N

Description

Biochem/physiol Actions

S29434 is a cell and blood-rain barrier penetrant, potent and selective inhibitor of quinone reductase 2 (QR2, NQO2) that inhibits production of ROS by QR2 in cells. S29434 triggers autophagy in human HepG2 cells. S29434 enhances exploring time of the unfamiliar object in mice memory test.

blood-brain barrier penetrant, potent and selective inhibitor of quinone reductase 2 (QR2)

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable