SML3293

3′,2′-Cgamp Disodium

≥98% (HPLC)

• Synonym(s): Adenylyl-(2′→5′)-3′-guanylic acid cyclic nucleotide disodium
• Empirical Formula (Hill Notation): C₂₀H₂₂N₁₀O₁₃P₂ ·2Na
• Molecular Weight: 718.38
• UNSPSC Code: 51111800
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• storage temp.: −20°C
• SMILES string: NC1=NC=NC2=C1N=CN2[C@H]3[C@H](OP4([O-])=O)[C@H](O)[C@@H](COP([O-])(O[C@H]5[C@@H](O)[C@H](N(C=N6)C7=C6C(NC(N)=N7)=O)O[C@@H]5CO4)=O)O3.[Na].[Na+]

Description

General description

3’,2’-cGAMP is a signaling molecule produced by the host immune system in response to pathogens. 3’,2’-cGAMP is synthesized from CdnG , one of the Cyclic-oligonucleotide-based antiphage signaling systems (CBASS). It activates the stimulator of interferon genes (STING)effector protein to initiate a potent interferon response. The drosophila STING (dSTING) in complex with 3′2′-cGAMP explains selective isomer recognition.

Biochem/physiol Actions

3′,2′-cGAMP is a bacterial second messenger involved in antiphage defense system. 3′,2′-cGAMP is a signaling molecule that activates Cap5 for DNA degradation in Asticcacaulis sp. and Lactococcus lactis. 3′2′-cGAMP is produced upon in Drosophila melanogaster upon activation by viral RNA or DNA of cGAS-like receptors (cGLRs) and induces antiviral response.

bacterial second messenger involved in antiphage defense system

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable