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SML3673

Sigma-Aldrich

Lin28 inhibitor C1632

≥98% (HPLC)

Synonym(s):

Lin28 1632, Lin28 inhibitor I, Lin28-C1632, Lin28-let-7 antagonist 1, N-Methyl-N-[3-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)phenyl]acetamide

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About This Item

Empirical Formula (Hill Notation):
C15H15N5O
CAS Number:
Molecular Weight:
281.31
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.28

Quality Level

Assay

≥98% (HPLC)

form

powder

color

, White to light Brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[n]21nc(ccc2nnc1C)c3cc(ccc3)N(C)C(=O)C

InChI

1S/C15H15N5O/c1-10-16-17-15-8-7-14(18-20(10)15)12-5-4-6-13(9-12)19(3)11(2)21/h4-9H,1-3H3

InChI key

WPAQLESUVYGUJZ-UHFFFAOYSA-N

Biochem/physiol Actions

Compound 1632 (C1632) is a RNA-binding protein Lin28 inhibitor that prevents Lin28-mediated inhibition of let-7 microRNA (miRNA) maturation by blocking Lin28 interaction with let-7 miRNA precursor (IC50 = 8 μM by ELISA using truncated pre-let-7a-2). C1632 specifically upregulates Huh7 cellular let-7a/g/f miRNA, but not RNU44 snoRNA (60 μM for 48h), inhibits the stemness and induces differentiation of mouse embryonic stem cells (mESCs, 20 μM for 48h), as well as inhibits the proliferation and stem-like properties of human cancer stem cells (CSCs) in 22Rv1 and Huh7 cultures (IC50 20-42 μM).
RNA-binding protein Lin28 inhibitor that prevents Lin28-mediated inhibition of let-7 microRNA (miRNA) maturation.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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