SML3873
Pip6 PARP-1 inhibitor
≥98% (HPLC)
Synonym(s):
(S)-4-(3-(3-(1,1-difluoroethyl)-6-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one
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About This Item
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
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This Item | 890703P | 890704P | 890703C |
|---|---|---|---|
| form liquid | form powder | form powder | form liquid |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in dry ice |
| manufacturer/tradename Avanti Research™ - A Croda Brand 890704C | manufacturer/tradename Avanti Research™ - A Croda Brand 890703P | manufacturer/tradename Avanti Research™ - A Croda Brand | manufacturer/tradename Avanti Research™ - A Croda Brand 890703C |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| packaging pkg of 1 × 2.5 mL (890704C-25mg), pkg of 2 × 4 mL (890704C-200mg), pkg of 1 × 4 mL (890704C-100mg) | packaging pkg of 1 × 25 mg (890703P-25mg) | packaging pkg of 1 × 100 mg (890704P-100mg), pkg of 2 × 100 mg (890704P-200mg), pkg of 1 × 25 mg (890704P-25mg) | packaging pkg of 1 × 2.5 mL (890703C-25mg) |
| concentration 10 mg/mL (890704C-25mg), 25 mg/mL (890704C-200mg), 25 mg/mL (890704C-100mg) | concentration - | concentration - | concentration 10 mg/mL (890703C-25mg) |
Biochem/physiol Actions
Pip6 is a cell penetrant and potent inhibitor of PARP-1 (Poly (ADP-ribose) polymerase 1) that exhibits potent cytotoxicity in cancer cells. It appears that Pip6 improved cytotoxicity is due to enhanced target residence time on PARP-1.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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