SRP0412

Sestrin 2 human

recombinant, expressed in baculovirus infected Sf9 cells, ≥35% (SDS-PAGE)

• Synonym(s): HI95, SES2, SEST2
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in baculovirus infected Sf9 cells
• Assay: ≥35% (SDS-PAGE)
• form: aqueous solution
• mol wt: 55 kDa
• packaging: pkg of 50 μg
• NCBI accession no.: NM_031459
• UniProt accession no.: P58004
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... SESN2(83667)

Description

General description

Sestrin 2 (SESN2), a highly conserved protein, is a member of a family of anti-aging proteins called the sestrins. Human SESN2 (hSESN2) contains three subdomains, such as SESN-A, SESN-B, and SESN-C. The SESN2 gene is mapped to human chromosome 1p35.3.

Application

Sestrin 2 human may be used to study its role on blood brain- barrier (BBB) stabilization after moderate and severe hypoxic- ischemic (HI) injuries in neonatal rats.

Biochem/physiol Actions

Sestrin 2 (SESN2) plays a vital role in modulating cellular stress response and oxidant defense. It plays a regulatory role in energy metabolism, cell fate, liver diseases, inflammation, and carcinogenesis. This novel anti-aging protein aids to maintain mitochondrial activities and enhance mitochondrial health. Since SESN2 is capable of protecting tissues from oxidative stress and mitochondrial dysfunction caused by ischemia or reperfusion (I/R), it may be a promising therapeutic target in hepatic regeneration.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable