T1157

(+)-α-Tocopherol acetate

BioReagent, suitable for insect cell culture, ~1360 IU/g

• Synonym(s): Vitamin E acetate
• Empirical Formula (Hill Notation): C₃₁H₅₂O₃
• CAS Number: 58-95-7
• Molecular Weight: 472.74
• EC Number: 200-405-4
• MDL number: MFCD00072052
• UNSPSC Code: 12352205
• eCl@ss: 34058007
• PubChem Substance ID: 24899940
• NACRES: NA.75

Properties

• biological source: plant
• description: Synthesized from natural α-tocopherol
• product line: BioReagent
• form: liquid (or semi-solid)
• specific activity: ~1360 IU/g
• mol wt: M_w 472.74 g/mol
• purified by: crystallization
• technique(s): cell culture | insect: suitable
• color: white to yellow
• solubility: chloroform: soluble 50 mg/mL, clear, colorless to yellow
• storage temp.: room temp
• SMILES string: CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1
• InChI: 1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1
• InChI key: ZAKOWWREFLAJOT-CEFNRUSXSA-N

Description

General description

α-Tocopherol acetate is a semisynthetic acetate ester of naturally occurring α-tocopherol.

Application

(+)-α-Tocopherol acetate has been used:

• as a supplement in the human embryonic kidney cells (HEK 293) to assess its impact on cell growth
• as a component of Dulbecco′s Modified Eagle Medium/Nutrient Mixture F-12 (DMEM/F12) for immortalized chondrocyte cell line
• as a component of serum-free medium for human colon tissue organ culture
• to test its antioxidant effects on cow articular chondrocytes

Use in insect cell culture applications as an antioxidant.

Biochem/physiol Actions

α-Tocopherol acetate or vitamin E-acetate has antioxidant properties and reduces lipid peroxidation. However, vitamin E acetate on pyrolysis leads to the generation of carcinogens like alkenes and benzenes.

Caution

Since the M.P. is about 25 °C this preparation is usually an oil. Does not air oxidize.

Safety Information

• Hazard Statements: H413
• Precautionary Statements: P273 - P501
• Hazard Classifications: Aquatic Chronic 4
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves