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T3411

Sigma-Aldrich

Tetramethylammonium chloride solution

Synonym(s):

N,N,N-Trimethylmethanaminium chloride

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352107
PubChem Substance ID:
NACRES:
NA.31

grade

Molecular Biology

Quality Level

concentration

5 M

foreign activity

DNase, RNase, none detected

SMILES string

[Cl-].C[N+](C)(C)C

InChI

1S/C4H12N.ClH/c1-5(2,3)4;/h1-4H3;1H/q+1;/p-1

InChI key

OKIZCWYLBDKLSU-UHFFFAOYSA-M

General description

Tetramethylammonium binds AT-rich DNA polymers while concomitantly abolishing the preferential melting of AT versus GC base pairs. It is supplied as a 0.2 μm filtered solution in 18 megohm water.

Application

Tetramethylammonium chloride solution (TMAC) has been used:
  • in the preparation of hybridization cocktail for array hybridization and scanning
  • in next-generation sequencing (NGS), and genome-wide unbiased identification of double-stranded breaks enabled by sequencing (GUIDE-seq) library preparation
  • in the preparation of TMAC buffer and bead hybridization mixture for hybridization and detection


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