T3439

Tumor Necrosis Factor Soluble Receptor I (TNF sRI)/Fc Chimera human

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

• MDL number: MFCD02689207
• UNSPSC Code: 51111800
• NACRES: NA.32

Properties

• biological source: human
• Quality Level: 100
• recombinant: expressed in NSO cells
• Assay: >95% (SDS-PAGE)
• form: lyophilized powder
• potency: 0.4-1 ng/mL ED₅₀
• mol wt: 48 kDa
• packaging: pkg of 50 μg
• storage condition: avoid repeated freeze/thaw cycles
• technique(s): cell culture | mammalian: suitable
• impurities: endotoxin, tested
• UniProt accession no.: P20333
• storage temp.: −20°C
• Gene Information: human ... TNFRSF1B(7133)

Description

Application

Tumor Necrosis Factor Soluble Receptor I (TNF sRI)/Fc Chimera human may be used to study signaling of apoptosis and NF-κB activation.

Biochem/physiol Actions

Tumor Necrosis Factor Soluble Receptor I (TNF sRI)/Fc Chimera human belongs to TNF family of receptors and has a pivotal role in neutralizing the biological activities of both TNF-α and TNF-β. Soluble tumor necrosis factor receptor along with intrathecal interleukin-1 receptor antagonist shows an anti-allodynic action in rat L5 spinal nerve transection model of neuropathic pain.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 2.5 mg bovine serum albumin.

Analysis Note

The biological activity is measured by its ability to neutralize apoptosis of mouse L-929 cells treated with 0.25 ng/ml recombinant human TNF-α.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable