T5575

TG003

≥98% (HPLC)

• Synonym(s): (Z)-1-(3-Ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene)propan-2-one
• Empirical Formula (Hill Notation): C₁₃H₁₅NO₂S
• CAS Number: 300801-52-9
• Molecular Weight: 249.33
• MDL number: MFCD00624584
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278611
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• mp: 132-132.5 °C
• solubility: DMSO: 33 mg/mL
• storage temp.: 2-8°C
• SMILES string: CCN1\C(Sc2ccc(OC)cc12)=C\C(C)=O
• InChI: 1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3/b13-7-
• InChI key: BGVLELSCIHASRV-QPEQYQDCSA-N

Description

Application

TG003 has been used in PAC1 cell culture and in vitro kinase assays.

TG003 has been used to develop assays for screening substances that affect mRNA splicing¹.

Biochem/physiol Actions

Potent, specific, reversible, and ATP-competitive inhibitor of Cdc2-like kinase (Clk). K_i = 10 nM for mClk1/Sty; IC₅₀ = 15 nM, 20 nM, 200 nM, and > 10 mM for mClk4, mClk1, mClk2, and mClk3, respectively.

TG003 regulates alternative splicing and reduces the phosphorylation of SF2/ASF1.

TG003, a CLK (cdc2-like kinase) family inhibitor is used as a drug for duchenne muscular dystrophy.

Packaging

Packaged under nitrogen.

Preparation Note

TG003 is soluble in DMSO at 33 mg/ml.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves