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V3765

Sigma-Aldrich

VU0255035 hydrate

≥98% (HPLC)

Synonym(s):

CID24768606, ML012, N-(3-oxo-3-(4-(pyridine-4-yl)piperazin-1-yl)propyl)benzo[c][1,2,5]thiadiazole-4-sulfonamide hydrate, N-[3-oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide hydrate

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10 G
MYR 615.00

MYR 615.00


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10 G
MYR 615.00

About This Item

Empirical Formula (Hill Notation):
C18H20N6O3S2 · xH2O
CAS Number:
Molecular Weight:
432.52 (anhydrous basis)
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

MYR 615.00


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Quality Level

Assay

≥98% (HPLC)

form

powder

color

yellow

solubility

DMSO: >5 mg/mL

storage temp.

−20°C

SMILES string

O.O=C(CCNS(=O)(=O)c1cccc2nsnc12)N3CCN(CC3)c4ccncc4

InChI

1S/C18H20N6O3S2.H2O/c25-17(24-12-10-23(11-13-24)14-4-7-19-8-5-14)6-9-20-29(26,27)16-3-1-2-15-18(16)22-28-21-15;/h1-5,7-8,20H,6,9-13H2;1H2

InChI key

NURHGMDBQMBSQI-UHFFFAOYSA-N

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This Item
359521.00201PHR1047
Phenol PESTANAL®, analytical standard

35952

Phenol

Phenol EMPROVE® ESSENTIAL, Ph. Eur., ChP, JP, USP

1.00201

Phenol

Phenol Pharmaceutical Secondary Standard; Certified Reference Material

PHR1047

Phenol

assay

≥99% (GC)

assay

-

assay

99.0-100.5% (bromatometric)

assay

-

Quality Level

100

Quality Level

100

Quality Level

500

Quality Level

300

solubility

water: soluble

solubility

-

solubility

-

solubility

-

form

crystalline solid

form

-

form

solid

form

-

storage temp.

−20°C

storage temp.

-

storage temp.

15-25°C

storage temp.

2-8°C

mp

40-42 °C (lit.)

mp

40-42 °C (lit.)

mp

40-42 °C (lit.)

mp

40-42 °C (lit.)

Biochem/physiol Actions

VU0255035 is the first highly selective antagonist at the orthosteric site of the M1 receptor (75-fold selective for M1 relative to other muscarininc subtypes and devoid of activity at other GPCRs, ion channels, transporters and kinases).
VU0255035 is the first highly selective antagonist at the orthosteric site of the M1 receptor (75-fold selective for M1 relative to other muscarininc subtypes and devoid of activity at other GPCRs, ion channels, transporters and kinases). There are no highly selective M1 muscarinic receptor antagonists. The existing non-selective drugs do not permit direct evaluation of the role of M1 receptors in CNS fucntions and do not premit therapeutic targeting of M1 receptors in various disease states in which M1 receptors are implicated (epilepsy, Parkinson′s disease, attention and cognitive disorders, dystonia, etc).

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Preparation and biological activity of various 3-deazapyrimidines and related nucleosides.
A Bloch et al.
Journal of medicinal chemistry, 16(3), 294-297 (1973-03-01)
Pyridone-carboxylic Acids as Antibacterial Agents. I. Synthesis and Antibacterial Activity of 1-Alkyl-1, 4-dihydro-4-oxo-1, 8-and 1, 6-naphthyridine-3-carboxylic Acids.
Hirose T, et al.
Chemical & Pharmaceutical Bulletin, 30(7), 2399-2409 (1982)
A highly active catalyst for Suzuki-Miyaura cross-coupling reactions of heteroaryl compounds.
Kelvin L Billingsley et al.
Angewandte Chemie (International ed. in English), 45(21), 3484-3488 (2006-04-28)

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