X2254

XE-991

≥98% (HPLC), powder, KCNQ channel blocker

• Synonym(s): 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone
• Empirical Formula (Hill Notation): C₂₆H₂₀N₂O
• CAS Number: 122955-42-4
• Molecular Weight: 376.45
• MDL number: MFCD05662331
• UNSPSC Code: 12352200
• PubChem Substance ID: 329830775
• NACRES: NA.77

Properties

• Product Name: XE-991, ≥98% (HPLC)
• Quality Level: 100
• Assay: ≥98% (HPLC)
• color: white to beige
• solubility: DMSO: >20 mg/mL
• originator: Merck & Co., Inc., Kenilworth, NJ, U.S.
• storage temp.: 2-8°C
• SMILES string: O=C1c2ccccc2C(Cc3ccncc3)(Cc4ccncc4)c5ccccc15
• InChI: 1S/C26H20N2O/c29-25-21-5-1-3-7-23(21)26(17-19-9-13-27-14-10-19,18-20-11-15-28-16-12-20)24-8-4-2-6-22(24)25/h1-16H,17-18H2
• InChI key: KHJFBUUFMUBONL-UHFFFAOYSA-N

Description

Application

XE-991 has been used as a KCNQ (Kv7.2/7.3) inhibitor to examine whether M-current inhibition affects oxytocin receptor (TGOT) mediated depolarization. It has also been used as an KCNQ inhibitor to study the ionic mechanism responsible for the overshoot/undershoot in membrane potential in mouse cholinergic interneurons (ChIs) in the presence of tetrodotoxin (TTX).

Biochem/physiol Actions

XE-991 is a KCNQ channel blocker.

XE-991 is a KCNQ channel blocker; which is more potent than linopiridine (Cat. No. L-134).

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable