1129007

Chlortetracycline hydrochloride

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): 7-Chlorotetracycline hydrochloride
• Empirical Formula (Hill Notation): C₂₂H₂₃ClN₂O₈ · HCl
• CAS Number: 64-72-2
• Molecular Weight: 515.34
• Beilstein: 3858364
• MDL number: MFCD00082440
• UNSPSC Code: 41116107
• PubChem Substance ID: 329749348
• NACRES: NA.24

Properties

• grade: pharmaceutical primary standard
• API family: chlortetracycline
• form: solid
• manufacturer/tradename: USP
• mp: 210-215 °C (dec.) (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: −20°C
• SMILES string: Cl.CN(C)[C@H]1[C@@H]2CC3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)ccc(Cl)c4[C@@]3(C)O
• InChI: 1S/C22H23ClN2O8.ClH/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21;/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31);1H/t7?,8-,15-,21-,22-;/m0./s1
• InChI key: CBHYYLPALVVVEY-LYNLVHCPSA-N

Description

General description

Chlortetracycline hydrochloride is a first-generation tetracycline antibiotic with activity against a wide spectrum of bacteria. It functions by preventing aminoacyl-tRNA attachment to the bacterial ribosome. The USP standard aids in identity verification and quantitative assay testing.

The USP biologics antibiotics category includes a wide range of antimicrobial agents that are essential in treating bacterial infections. These antibiotics are derived from various natural sources or synthesized to combat specific pathogens effectively. The USP provides comprehensive standards, reference materials, and analytical procedures to ensure the identity, quality, purity, and consistency of antibiotic therapeutics throughout their lifecycle.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

Application

Chlortetracycline hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:

• Chlortetracycline Hydrochloride Ointment
• Chlortetracycline Hydrochloride Tablets
• Chlortetracycline Hydrochloride Soluble Powder
• Chlortetracycline Hydrochloride Ophthalmic Ointment
• Chlortetracycline and Sulfamethazine Bisulfates Soluble Powder
• Chlortetracycline Bisulfate

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

This product is part of the USP Biologics program.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopeia.

Sales restrictions may apply.

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Warning
• Hazard Statements: H315,H317,H319,H335,H361fd
• Precautionary Statements: P202 - P261 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable