226351

N-Hydroxymaleimide

97%, for peptide synthesis

• Synonyme(s) : 1-Hydroxypyrrole-2,5-dione
• Formule empirique (notation de Hill) : C₄H₃NO₃
• CAS Number: 4814-74-8
• Poids moléculaire : 113.07
• Beilstein: 1524594
• Numéro CE : 225-385-4
• Numéro MDL: MFCD00005501
• Code UNSPSC : 12352005
• ID de substance PubChem : 24853562
• Nomenclature NACRES : NA.22

Propriétés

• Product Name: N-Hydroxymaleimide, 97%
• Niveau de qualité: 200
• Essai: 97%
• Forme: solid
• Capacité de réaction: reaction type: Addition Reactions
• Pf: 130-133 °C (dec.) (lit.)
• Application(s): peptide synthesis
• Groupe fonctionnel: imide; maleimide
• Chaîne SMILES: ON1C(=O)C=CC1=O
• InChI: 1S/C4H3NO3/c6-3-1-2-4(7)5(3)8/h1-2,8H
• Clé InChI: BUXKULRFRATXSI-UHFFFAOYSA-N

Description

Description générale

N-Hydroxymaleimide (NHMI) is an organic compound that is widely used as an oxidizing agent in organic synthesis. It is frequently used to selectively oxidize thiols to disulfides and in the synthesis of α, β-unsaturated carbonyl compounds. It can also act as a Michael acceptor and is used in the synthesis of peptides and proteins.

Application

N-Hydroxymaleimide can be used as an oxidant to generate N-hydroxy anilines in situ, which serve as key intermediates in the selective coupling reaction of N-substituted anilines with hydroxylamine derivatives, for the efficient synthesis of aromatic oximes.

Informations sur la sécurité

• Pictogrammes: GHS05
• Mention d'avertissement: Danger
• Mentions de danger: H314
• Conseils de prudence: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Classification des risques: Eye Dam. 1 - Skin Corr. 1B
• Code de la classe de stockage: 8A - Combustible corrosive hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges