245801

N-(Hydroxymethyl)acrylamide solution

48 wt. % in H₂O

• Synonyme(s) : Monomethylolacrylamide, N-(Hydroxymethyl)acrylamide, N-Methanolacrylamide
• Formule linéaire : CH₂=CHCONHCH₂OH
• CAS Number: 924-42-5
• Poids moléculaire : 101.10
• Beilstein: 506646
• Numéro MDL: MFCD00004597
• Code UNSPSC : 12162002
• ID de substance PubChem : 24854759
• Nomenclature NACRES : NA.23

Propriétés

• Forme: liquid
• Contient: 30 ppm monomethyl ether hydroquinone as inhibitor
• Concentration: 48 wt. % in H₂O
• Indice de réfraction: n20/D 1.413
• Densité: 1.074 g/mL at 25 °C
• Chaîne SMILES: OCNC(=O)C=C
• InChI: 1S/C4H7NO2/c1-2-4(7)5-3-6/h2,6H,1,3H2,(H,5,7)
• Clé InChI: CNCOEDDPFOAUMB-UHFFFAOYSA-N

Description

Description générale

N-(Hydroxymethyl)acrylamide (NHMA) is a bifunctional monomer with both a reactive vinyl group and a hydroxymethyl group, making it significant in polymer chemistry. It is known for forming hydrophilic, cross-linked networks, with applications in biomedical fields such as drug delivery systems, contact lenses, and tissue engineering, as well as in industrial UV-curable resins. NHMA is commonly used in hydrogel formulations for drug delivery and wound dressings. Additionally, it can be applied in creating bioadhesives or sealants for medical purposes, such as sealing wounds or attaching medical devices to tissues.

Application

N-(Hydroxymethyl)acrylamide can be used as:

• A monomer in the development of polymer gel dosimeters specifically designed for radiation therapy applications. The incorporation of NHMA enhances the sensitivity of the dosimeter to radiation doses.
• A monomer in the development of thermo-responsive polymeric gates, which exhibits thermo-responsive behavior. The incorporation of NHMA enhances the overall properties of the polymer, allowing for better control over the release mechanisms in response to temperature changes.
• A key monomer in the synthesis of double-hydrophilic and amphiphilic block glycopolymers, contributing to their self-assembly properties, biocompatibility, and functionalization potential. These characteristics make NHMA-based glycopolymers valuable for various biomedical applications, including drug delivery systems, biosensors, and tissue engineering.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H301,H317,H340,H350,H361,H372,H373
• Conseils de prudence: P202 - P260 - P264 - P280 - P301 + P310 - P302 + P352
• Classification des risques: Acute Tox. 3 Oral - Carc. 1B - Muta. 1B - Repr. 2 - Skin Sens. 1 - STOT RE 1 - STOT RE 2 Oral
• Organes cibles: Peripheral nervous system
• Code de la classe de stockage: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter