299634

6-(5H)-Phenanthridinone

technical grade

• Synonyme(s) : NSC 11021, NSC 40943, NSC 61083
• Formule empirique (notation de Hill) : C₁₃H₉NO
• CAS Number: 1015-89-0
• Poids moléculaire : 195.22
• Numéro CE : 213-804-3
• Numéro MDL: MFCD00004988
• Code UNSPSC : 12352100
• ID de substance PubChem : 24858050
• Nomenclature NACRES : NA.22

Propriétés

• Qualité: technical grade
• Niveau de qualité: 100
• Forme: powder
• Pf: 290-292 °C (lit.)
• Chaîne SMILES: O=C1Nc2ccccc2-c3ccccc13
• InChI: 1S/C13H9NO/c15-13-11-7-2-1-5-9(11)10-6-3-4-8-12(10)14-13/h1-8H,(H,14,15)
• Clé InChI: RZFVLEJOHSLEFR-UHFFFAOYSA-N
• Informations sur le gène: human ... PARP1(142)

Description

Description générale

6-(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose)polymerase (PARP)-1 activity. The ability of 6-(5H)-phenanthridinone to potentiate the effect of ionizing radiation on tumour cells was evaluated. Action of 6-(5H)-phenanthridinone, one of the most potent PARP inhibitor, on RDM4 murine lymphoma cells in culture was evaluated.

Application

Reactant involved in:

• Synthesis of 5,6-dihydrophenanthridine sulfonamides
• Oxidative coupling with diphenylacetylene
• Direct copper acetate-catalyzed N-cyclopropylation of cyclic amides

Reactant involved in the synthesis and/or pharmacological activity of biologically active molecules including:

• Potassium channel KV1.3 and IK-1 inhibitors
• HIV-1 integrase inhibitors

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)