37580

3,4-Dihydroxybenzoic acid

≥97.0% (T)

• Synonyme(s) : Protocatechuic acid
• Formule linéaire : (HO)₂C₆H₃CO₂H
• CAS Number: 99-50-3
• Poids moléculaire : 154.12
• Beilstein: 1448841
• Numéro CE : 202-760-0
• Numéro MDL: MFCD00002509
• Code UNSPSC : 12352100
• ID de substance PubChem : 57649743
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 200
• Essai: ≥97.0% (T)
• Pf: 197-200 °C (dec.) (lit.)
• Groupe fonctionnel: carboxylic acid
• Chaîne SMILES: OC(=O)c1ccc(O)c(O)c1
• InChI: 1S/C7H6O4/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,8-9H,(H,10,11)
• Clé InChI: YQUVCSBJEUQKSH-UHFFFAOYSA-N

Description

Description générale

3,4-Dihydroxybenzoic acid is reported as dietery polyphenol. Antiviral activity of 3,4-dihydroxybenzoic acid (protocatechuic acid, PCA) against a virulent H9N2 strain in a mouse model is reported. Cytotoxic effects of PCA on 3 non-small cell lung cancer (NSCLC) cell lines, A549, H3255, and Calu-6 cell lines is reported. PCA is reported to prevent the carcinogenesis or antitumor growth in vivo. Signaling pathway involved in PCA-induced apoptosis in human gastric adenocarcinoma (AGS) cells is reported. The oxidation of 3,4-dihydroxybenzoic acid by H₂O₂ in aqueous/goethite slurry at varying operating conditions (catalyst load, temperature, pH, substrate and hydrogen peroxide starting concentration) is investigated.

Application

3,4-Dihydroxybenzoic acid is suitable for use in a study to investigate the effect of 4-coumaric and 3,4-dihydroxybenzoic acid on the basal oxidative DNA damage of rat colonic mucosa in vivo. It may be used in the derivatization of chitosan resin.

Actions biochimiques/physiologiques

Chemopreventive in several animal models of carcinogenesis. Blocks cell proliferation in the post-initiation phase.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves