396494

Aminoguanidine hydrochloride

≥98%

• Synonyme(s) : Guanylhydrazine hydrochloride
• Formule linéaire : NH₂NHC(=NH)NH₂ · HCl
• CAS Number: 1937-19-5
• Poids moléculaire : 110.55
• Beilstein: 3909606
• Numéro CE : 217-707-7
• Numéro MDL: MFCD00039074
• Code UNSPSC : 12352100
• ID de substance PubChem : 24864672
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 200
• Essai: ≥98%
• Forme: solid
• Pf: 162-166 °C (lit.)
• Groupe fonctionnel: amine; hydrazine
• Chaîne SMILES: Cl.NNC(N)=N
• InChI: 1S/CH6N4.ClH/c2-1(3)5-4;/h4H2,(H4,2,3,5);1H
• Clé InChI: UBDZFAGVPPMTIT-UHFFFAOYSA-N

Description

Description générale

Aminoguanidine hydrochloride has been reported in a study as inhibitor of animal nitric oxide (NO)-synthase. Crystal structure of aminoguanidine hydrochloride has been investigated by Fourier and least squares method. Its crystals were monoclinic and the guanidine part of the aminoguanidinium ion is planar.

Application

Aminoguanidine hydrochloride may be employed as nitric oxide synthase (NOS) inhibitor to investigate its effect on the reduction of alveolar bone loss in ligature induced periodontitis in rats. It may be used in the synthesis of 5-guanylhydrazone derivatives, having antibacterial activity against antibacterial activity against both Escherichia coli and Staphylococcus aureus.

Actions biochimiques/physiologiques

Inhibits both constitutive and inducible nitric oxide synthetase.

Informations sur la sécurité

• Pictogrammes: GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H317,H411
• Conseils de prudence: P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
• Classification des risques: Aquatic Chronic 2 - Skin Sens. 1B
• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves