408719

Polyethylenimine, ethylenediamine end-capped

average M_w ~800 by LS, average M_n ~600 by GPC

• Synonyme(s) : PEI, ethylenediamine branched
• Formule linéaire : H(NHCH₂CH₂)_nNH₂
• CAS Number: 25987-06-8
• Numéro MDL: MFCD00084427
• Code UNSPSC : 12162002
• Nomenclature NACRES : NA.23

Propriétés

• Forme: viscous liquid
• Niveau de qualité: 200
• Poids mol.: average M_n ~600 by GPC; average M_w ~800 by LS
• Indice de réfraction: n20/D 1.5240
• Densité: 1.050 g/mL at 25 °C
• Chaîne SMILES: N1CC1.NCCN
• InChI: 1S/C2H8N2.C2H5N/c3-1-2-4;1-2-3-1/h1-4H2;3H,1-2H2
• Clé InChI: SFLOAOINZSFFAE-UHFFFAOYSA-N

Description

Description générale

Polyethyleneimine is a hydrophilic polymerwidely used as a non-viral synthetic vector for invivo delivery of therapeutic nucleic acids. Owing to its excellentphysicochemical properties, it is applied in many fields like the separationand purification of proteins, carbon dioxide absorption, drug carriers,effluent treatment, and biological labels.

Application

Branched PEI can be used as a precursor to synthesize conjugated polyplexes for efficient gene transfection. Conjugation of PEI with Jeffamine polyether and guanidinylation of the amino groups of PEI reduce the cytotoxicity of the polyplexes and protect them from aggregation in the presence of serum proteins.

Bamboo charcoal impregnated with PEI can be used as a CO₂ adsorbent. Numerous amino groups present in PEI can react with CO₂ due to acid-alkali interaction and enhance the adsorption capacity of bamboo charcoal.

It can also be used to prepare cross-linked water-soluble polymers with high coordination capabilities towards organic drug molecules.

Caractéristiques et avantages

• Branched PEI has better complexation and buffering capacity.
• High ion exchange capacity and affinity toward proteins.
• SignificantDNA transfer efficiency.

Forme physique

Branched polymer

Informations sur la sécurité

• Pictogrammes: GHS05,GHS07,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H302,H318,H411
• Conseils de prudence: P264 - P273 - P280 - P301 + P312 - P305 + P351 + P338 - P391
• Classification des risques: Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1
• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): 356.0 °F
• Point d'éclair (°C): 180 °C
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter