638099

CyJohnPhos

97%

• Synonyme(s) : 2-(Dicyclohexylphosphino)biphenyl, (2-Biphenyl)dicyclohexylphosphine, Cyclohexyl JohnPhos
• Formule empirique (notation de Hill) : C₂₄H₃₁P
• CAS Number: 247940-06-3
• Poids moléculaire : 350.48
• Beilstein: 8440533
• Numéro MDL: MFCD01862441
• Code UNSPSC : 12352002
• ID de substance PubChem : 24882909
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 100
• Essai: 97%
• Capacité de réaction: reaction type: Cross Couplings
• Pertinence de la réaction: reagent type: ligand; reaction type: Arylations; reagent type: ligand; reaction type: Buchwald-Hartwig Cross Coupling Reaction; reagent type: ligand; reaction type: C-X Bond Formation; reagent type: ligand; reaction type: Hiyama Coupling; reagent type: ligand; reaction type: Methylations; reagent type: ligand; reaction type: Negishi Coupling; reagent type: ligand; reaction type: Oxidations; reagent type: ligand; reaction type: Suzuki-Miyaura Coupling
• Pf: 102-106 °C (lit.)
• Groupe fonctionnel: phosphine
• Chaîne SMILES: C1CCC(CC1)P(C2CCCCC2)c3ccccc3-c4ccccc4
• InChI: 1S/C24H31P/c1-4-12-20(13-5-1)23-18-10-11-19-24(23)25(21-14-6-2-7-15-21)22-16-8-3-9-17-22/h1,4-5,10-13,18-19,21-22H,2-3,6-9,14-17H2
• Clé InChI: LCSNDSFWVKMJCT-UHFFFAOYSA-N

Description

Description générale

CyJohnPhos [(2-Biphenyl)dicyclohexylphosphine] is an air-stable, bulky and electron-rich monodentate biarylphosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.

Learn more about Buchwald Phosphine Ligands

Application

CyJohnPhos may be used in combination with a nickel catalyst for the Suzuki-Miyaura arylation of tertiary benzylic acetates with aryl boroxines to produce diaryl and triaryl quaternary stereocenters.

Ligand employed in the palladium-catalysed synthesis of 1,3,5-tris(2′-aminophenyl)benzene, a core building block for potential ionic receptors.

Ligand for amination of aryl halides and triflates.

Informations légales

Usage subject to US Patents 6307087 and 6395916.

Informations sur la sécurité

• Mentions de danger: H413
• Classification des risques: Aquatic Chronic 4
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)