706531

N-Boc-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester

95%

• Synonyme(s) : (1-tert-Butoxycarbonyl-1,2,3,6-tetrahydropyridin-4-yl)boronic acid pinacol ester, (N-tert-Butoxycarbonyl-1,2,3,6-tetrahydropyridin-4-yl)boronic acid pinacol ester, (N-tert-Butoxycarbonyl-1,2,5,6-tetrahydropyridin-4-yl)boronic acid pinacol ester, (N-tert-Butoxycarbonyl)-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester
• Formule empirique (notation de Hill) : C₁₆H₂₈BNO₄
• CAS Number: 286961-14-6
• Poids moléculaire : 309.21
• Numéro MDL: MFCD03840345
• Code UNSPSC : 12352103
• ID de substance PubChem : 329762650
• Nomenclature NACRES : NA.22

Propriétés

• Niveau de qualité: 100
• Essai: 95%
• Forme: powder
• Pf: 100-114 °C
• Chaîne SMILES: CC(C)(C)OC(=O)N1CCC(=CC1)B2OC(C)(C)C(C)(C)O2
• InChI: 1S/C16H28BNO4/c1-14(2,3)20-13(19)18-10-8-12(9-11-18)17-21-15(4,5)16(6,7)22-17/h8H,9-11H2,1-7H3
• Clé InChI: VVDCRJGWILREQH-UHFFFAOYSA-N

Description

Description générale

Boc-THP-Bpin is frequently used in metal catalyzed cross-coupling reactions, such as Suzuki-Miyaura and Negishi couplings.

Application

Reagent used for

• Suzuki-Miyaura cross-coupling using palladium phosphine catalyst
• Palladium-catalyzed ligand-controlled regioselective Suzuki coupling
• Palladium-catalyzed Suzuki-Miyaura coupling
• Suzuki coupling followed by iodolactonization reaction
• Wrenchnolol derivative optimized for gene activation in cells

Reagent used in Preparation of several enzymatic inhibitors and receptor ligands

• Orally active anaplastic lymphoma kinase inhibitors
• Oxazolecarboxamides as diacylglycerol acyltransferase-1 inhibitors for treatment of obesity and diabetes
• 4-arylpiperidinyl amides and N-arylpiperidin-3-yl-cyclopropanecarboxamides as novel melatonin receptor ligands
• Quinazoline analogs as glucocerebrosidase inhibitors with chaperone activity for treatment of Gaucher disease, a lysosomal storage disorder
• Arylpiperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)