707066

DCA Deblock (0.36M dichloroacetic acid in toluene)

• Synonyme(s) : DCA Deblock, DEBLOCK (0.36M dichloroacetic acid in toluene)
• Formule empirique (notation de Hill) : C₂H₂Cl₂O₂
• CAS Number: 79-43-6
• Poids moléculaire : 128.94
• Numéro MDL: MFCD00004223
• Code UNSPSC : 12352106
• ID de substance PubChem : 329762686

Propriétés

• Forme: liquid
• Niveau de qualité: 100
• Concentration: ≤100 ppm in H₂O
• pb: 110-111 °C
• Densité: 0.884 g/mL at 25 °C
• Chaîne SMILES: OC(=O)C(Cl)Cl
• InChI: 1S/C2H2Cl2O2/c3-1(4)2(5)6/h1H,(H,5,6)
• Clé InChI: JXTHNDFMNIQAHM-UHFFFAOYSA-N

Description

Description générale

Deblock solution, containing dichloroacetic acid (DCA) in dichloromethane or Toluene, removes the dimethoxytrityl (DMT) protecting the group from the 5′ hydroxyl moiety of nucleotides already incorporated into the growing nucleic acid, prior to the addition of the next phosphoramidite. Removal of the DMT allows the unprotected 5′ hydroxyl moiety to react with a new phosphoramidite in a subsequent extension reaction.

Application

DCA Deblock (0.36M dichloroacetic acid in toluene) is suitable for the removal of 4,4Adimethoxytrityl (DMTr) protecting groups for the synthesis of antisense oligonucleotides in high yield and purity.

Informations sur la sécurité

• Pictogrammes: GHS02,GHS08,GHS05,GHS07
• Mention d'avertissement: Danger
• Mentions de danger: H225,H304,H315,H318,H336,H351,H360FD,H362,H373,H412
• Conseils de prudence: P210 - P263 - P280 - P301 + P310 - P305 + P351 + P338 - P331
• Classification des risques: Aquatic Chronic 3 - Asp. Tox. 1 - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Lact. - Repr. 1B - Skin Irrit. 2 - STOT RE 2 Inhalation - STOT SE 3
• Organes cibles: Central nervous system
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): 41.0 °F
• Point d'éclair (°C): 5 °C
• Équipement de protection individuelle: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter